Yongmei Chen, MD, PhD

Assistant Researcher

UCSF Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
San Francisco, CA 94110
phone: 415-206-4795
fax: 415-206-8907
email: meichen@anesthesia.ucsf.edu

Education and Training

• PhD, Neuroscience, 1998, University of Missouri-Columbia, Columbia, Missouri
• MD, Medicine, 1990, Hunan Medical University, Hunan, China

Research Interests

• Mechanisms underlying brain vascular malformations
• Novel strategies for promoting brain angiogenesis
• Roles for astrocytes in cerebral vessel formation

Selected Publications

• Chen Y., and Swanson RA. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem, 84:1332-1339, 2003

• Chen Y., and Swanson RA. Astrocytes and brain injury. J Cereb Blood Flow Metab (Review), 23:137-149, 2003

• Duan S., Anderson CM., Keung EC., Chen Y., and Swanson RA. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci. 23: 2003

• Ying W., Chen Y., Alano C., Swanson RA. Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. J Cereb Blood Flow Metab. 22:774-779, 2002

• Chen Y., Vartiainen NE., Ying W., Chan PH., Koistinaho J., Swanson RA. Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem. 77:1601-1610, 2001

• Ying W., Sevigny M., Chen Y., Swanson RA. Poly(ADP-ribose) glycohydrolase mediates excitotoxic and oxidative neuronal death. Proc Natl Acad Sci U S A. 98:12227-12232, 2001

• Chen Y., Chan PH., Swanson RA. Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury. Glia. 33:343-34, 2000

• Chen Y., Ying W., Simma V., Copin J-C., Chan PH., Swanson RA. Overexpression of Cu,Zn superoxide dismutase attenuates oxidative inhibition of astrocyte glutamate uptake. J Neurochem. 75:939-945, 2000

• Ying W., Anderson CM., Chen Y., Stein BA., Fahlman CS., Copin J-C., Chan PH., Swanson RA. Differing effects of copper, zinc dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins. J Cereb Blood Flow Metab. 20:359-368, 2000

• Chen Y., and Sun AY. Activation of AP-1 transcription factor after extracellular ATP treatment in PC12 cells. Neurochem Res. 23: 543-550, 1998

• Draczynska-Lusiak B., Chen Y., and Sun AY. Oxidized LDL activates NF-kB binding activity and induce apoptosis in PC12 cells. NeuroReport. 9: 527-532, 1998

• Sun AY., Chen Y. Oxidative stress and neurodegenerative disorders. J Biomed Sci (Review) 5: 401-414, 1998

• Sun AY., Chen Y., Cheng Y., and Wixom P. Ethanol enhanced lipid peroxidation and cell death in PC12 cells. Neurochem Res. 22:1187-1192, 1997

• Chen Y., Wixom P., and Sun AY. Enhanced (Na+K)-ATPase activity and expression in mouse brain after chronic ethanol administration. Neurochem Res. 22: 583-588, 1997

• Cheng Y. Chen Y., Wixom P. Sun AY. Extracellular ATP may induce neuronal degeneration by a free-radical mechanism. Ann N Y Acad Sci. 738:431-435, 1994

• Han C., Chen Y. Differential effects of hypoxia on vasoconstriction by different subtypes of a1-adrenoceptor. Acta Physiol Sinica. 45:178-182, 1993

• Chen Y., Han C. Analysis of a1-adrenoceptor and its subtypes in rat pulmonary artery. Acta Pharmacol Sinica. 13: 505-509, 1992

• Han C., Li J., Chen Y. Changes of a1-adrenoceptor subtypes in blood vessels of spontaneously hypertensive rats. Acta Physiologica Sinica. 44:15-21, 1992

• Han C., Chen Y. Two element analysis of a1-adrenoceptor mediated contraction in rat aorta. Journal of Beijing Medical University. 24:100-105, 1992

• Han C., Li J., Chen, Y., Wang X., Zhao Y. Alterations of a1-adrenoceptor and its subtypes in blood vessels isolated from endotoximia rats. Journal of Beijing Medical University. 24:169-172, 1992

• Chen Y., Wang X., Han C. Activation of ATP-dependent potassium channel is one of the mechanisms of vasodilation effect of calcitonin gene-related peptide. Journal of Beijing Medical University. 23:362-365, 1991