Tomoki Hashimoto, MD

Associate Professor

UCSF Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
San Francisco, CA 94110
phone: 415-206-8958
fax: 415-206-8907
email: hashimot@anesthesia.ucsf.edu

Education and Training

• MD, Gifu University, Japan
• Anesthesia Residency, Columbia Presbyterian Medical Center
• Neuroanesthesia Fellowship, Columbia Presbyterian Medical Center
• American Board of Anesthesiology

Research Interests

• Angiogenesis and vascular remodeling in cerebrovascular disease
• Anesthetic management for cerebrovascular disease
• Anesthetic management for interventional neuroradiology

Selected Publications

• Hashimoto T, Wu Y, Lawton MT, Yang GY, Barbaro NM, Young WL: Coexpression of angiogenic factors in brain arteriovenous malformations. Neurosurgery. 2005 May;56(5):1058-65; discussion 1058-65

• Yang GY, Yao JS, Huey M, Hashimoto T, Young WL: Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration. Neurochem Int. 44(6):441-6, May 2004

• Hashimoto T, Lawton MT, Wen G, Yang GY, Chaly T JR, T, Stewart CL, Dressman HK, Barbaro NM, Marchuk DA, Young WL: Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery 54(2): 410-425, February 2004

• Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang GY: Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J Cereb Blood Flow Metab. 24(2): 237-244, February 2004

• Yang, GY, Xu B, Hashimoto T, Huey M, Chaly Jr T, Wen R, and Young WL. Induction of focal angiogenesis through adenoviral vector mediated vascular endothelial cell growth factor gene transfer in the mature mouse brain. Angiogenesis. 6(2): 151-158, 2003

• Hashimoto T, Wen G, Lawton MT, Boudreau N, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL: Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke 34:925-931, 2003

• Hashimoto T, Gupta DK, Young WL: Interventional neuroradiology--anesthetic considerations. Anesthesiol Clin North America, 20(2):347-59, vi, 2002

• Quick CM, James DJ, Ning K, Joshi S, Halim AX, Hashimoto T, Young WL: Relationship of nidal vessel radius and wall thickness to brain arteriovenous malformation hemorrhage. Neurol Res, 24 (5):495-500, 2002

• Hashimoto T, Young WL, Prohovnik I, Gupta DK, Ostapkovich ND, Ornstein E, Halim AX, Quick CM: Increased cerebral blood flow after brain arteriovenous malformation resection is substantially independent of changes in cardiac output. J Neurosurg Anesthesiol, 14 (3): 204-8, 2002

• Gupta DK, Young WL, Hashimoto T, Halim AX, Marshall RS, Lazar RM, Joshi S, Pile-Spellman J, Ostapkovich N: Characterization of the cerebral blood flow response to balloon deflation after temporary internal carotid artery test occlusion. J Neurosurg Anesthesiol, 14 (2):123-9, 2002

• Young WL, Lawton MT, Gupta DK, Hashimoto T: Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping. Anesthesiology 96 (2): 497-503, 2002

• Hashimoto T, Young WL: Anesthesia-related considerations for cerebral arteriovenous malformations. Neurosurg Focus, 11 (5): Article 5, 2001

• Quick CM, Hashimoto T, Young WL: Lack of flow regulation may explain the development of arteriovenous malformations. Neurol Res 23: 641-644, 2001

• Hashimoto T, Lam T, Boudreau NJ, Bollen AW, Lawton MT, Young WL: Abnormal balance in the angiopoietin-Tie2 system in human brain arteriovenous malformations. Circulation Research 89(2):111-3, 2001

• Hashimoto T, Mesa-Tejada R, Quick CM, Bollen AW, Joshi S, Pile-Spellman J, Lawton MT, Young, WL: Evidence of increased endothelial cell turnover in brain arteriovenous malformations. Neurosurgery 49(1):124-132, 2001

• Joshi S, Hashimoto T, Ostapkovich N, Pile-Spellman J, Duong DH, Hacien-Bey L, Marshall RS, James DJ, Young WL. Effect of intracarotid papaverine on human cerebral blood flow and vascular resistance during acute hemispheric arterial hypotension. Journal of Neurosurgical Anesthesiology. Apr;13(2):146-51, 2001