Yoshitsugu Nuki, MD, PhD

Visiting Assistant Professor

UCSF Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
San Francisco, CA 94110
phone: 415-206-5667
fax: 415-206-8907
email: nukiy@anesthesia.ucsf.edu

Education and Training

• 1989; MD, Miyazaki Medical College, Japan
  
• 1989-; Member of Japan Neurosurgical Society and Japanese Congress of Neurological Surgeons
  
• 1989-1993; Graduate School of Miyazaki Medical College
  
• 1993; PhD, Miyazaki Medical College, Japan
  
• 1997; Board certified of Japan Neurosurgical Society
  
• 2000-; Member of Japan Stroke Society
  
• 2004-; International Member of the American Association of Neurological Surgeons (AANS),
  International Member of the European Neurological Society (ENS)
  
• 2005; Board certified of Japan Stroke Society
  
  
  

  Research Interests

• Cerebrovascular disease: SAH, Cerebral vasospasm, AVM, cerebral aneurysm,
  cerebral infarction, and clinical investigation of SAH or AVM.
  
  

  Selected Publications

• Yoshitsugu Nuki, Shunro Uchinokura, Shiro Miyata, Tuyoshi Fukushima, Ryoichi Hamasuna, Shinichi Nakano, Shinichiro Wakisaka, Yutaka Akiyama, Hiroshi Itoh and Hiroaki Kataoka: Establishment and characterization of a new human glioblastoma cell line, NYGM: Human cell 17(3), 33-41, 2004.
  
  
• Yoshitsugu Nuki, Shinichi Nakano, Naoki Asami, Takuzo Moriyama, Hisao Uehara, Hirokazu Kawano, Tomokazu Goya and Shinichiro Wakisaka : Fasudil Hydrochloride for Vasospasm After Early Surgery for Good Grade Patients with Subarachnoid Hemorrhage. R. Loch Macdonald: Cerebral Vasospasm. Advances in Research and Treatment: 288-291, 2004.
  
  
• Naganuma S, Itoh H, Uchiyama S, Tanaka H, Nagaike K, Miyata S, Uchinokura S, Nuki Y, Akiyama Y, Chijiiwa K, Kataoka H: Characterization of transcripts generated from mouse hepatocyte growth factor activator inhibitor type 2 (HAI-2) and HAI-2-related small peptide (H2RSP) genes: chimeric mRNA transcribed from both HAI-2 and H2RSP genes is detected in human but not in mouse. Biochem Biophys Res Commun 302(2): 345-353, 2003.
  
  
• Kataoka H, Itoh H, Nuki Y, Hamasuna R, Naganuma S, Kitamura N, Shimomura T: Mouse Hepatocyte Growth Factor (HGF) Activator Inhibitor Type 2 Lacking the First Kunitz Domain Potently Inhibits the HGF Activator. Biochem Biophys Res Commun 290(3): 1096-1100, 2002.
  
  
• Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M: Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): Its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Biochem Biophys Res Commun 288: 390-399, 2001.
  
  
• Hiroaki Kataoka, Hiroshi Itoh, Takeshi Shimomura, Yoshitsugu Nuki, Seiji Naganuma, Keiji Miyazawa: Regulation of Hepatocyte Growth Factor (HGF) Activation on Cell Surface: Insights into an Emerging Class of Cell Surface Protease Inhibitors. LifeXY, 1: 1036-1042, 2001.
  
  
• Kawasaki H, Nuki Y, Yamaga N, et al: Decreased depressor response mediated by calcitonin gene-related peptide (CGRP)-containing vasodilator nerves to spinal cord stimulation and levels of CGRP mRNA of the dorsal root ganglia in spontaneously hypertensive rats. Hypertens Res 23 (6): 693-699, 2000.
  
  
• Nuki Y, Kawasaki H, Taguchi T, et al: Effects of dorsal rhizotomy on depressor response to spinal cord stimulation mediated by endogenous calcitonin gene-related peptide in the pithed rat. J Neurosurg 79:899-904, 1993.