Hua Su, MD

Assistant Professor

San Francisco General Hospital
Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
Building 10, 2nd Floor, Room 1206
San Francisco, CA 94110
phone: 415-206-3162
fax: 415-206-8907
email: suh@anesthesia.ucsf.edu

Education and Training

• MD, Medicine, 1982, Nanjing Medical University, Nanjing, China
• MS, Histology and Embryology, 1985, Xian Medical University, Xian, China
• Postdoctoral Fellow, Reproductive Physiology, 1986, Beijing Medical University, Beijing, China
• Postdoctoral Fellow, Medical Genetics, 1992, University of California, San Francisco, CA

Research Interests

• Viral vector mediated targeted gene expression
• Gene and cell based therapies for ischemic heart disease
• Gene and cell based therapies for cerebral vascular diseases
• Development of rodent arteriovenous malformation model

Selected Publications

• H Kim, DA Marchuk, Y Chen, H Su, GY Yang, WL Young. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir, 2008 in press

• *H Su, J Takagawa, Y Huang, J Arakawa-Hoyt, J Pons, W Grossman and YW Kan. Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart. Int J Cardio. Online published 2008 (Feb). (*corresponding author)

• F Shen, Y Fan, H Su, Y Zhu, Y Chen, W Liu, WL Young and GY Yang. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Therapy, 15: 30-39, 2008

• *H Su, Y Yeghiazarians, A Lee, Y Huang, J Arakawa-Hoyt, J Ye, G Orcino, W Grossman and Y W Kan. AAV Serotype 1 Mediates more Efficient Gene Transfer to Pig Myocardium than AAV Serotype 2 and Plasmid. J Gene Med. Nov. 29, 2007. (*corresponding author)

• H Su and YW Kan. Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts. Methods Mol Biol. 366:331-42, 2007

• Q Hao, Y Chen, Y Zhu, Y Fan D Palmer, H Su, WL Young, and GY Yang. Neutrophil Depletion Decreases VEGF-Induced Focal Angiogenesis in the Mature Mouse Brain. Journal of Cerebral Blood Flow & Metabolism, 27:1853-1860, 2007.

• F Shen, H Su, Y Fan, Q Zhu, W Liu, WL Young, and GY Yang. Adeno-Associated Viral Vector-Mediated Hypoxia-Response Element-Regulated Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury Following Focal Cerebral Ischemia in Mice. Stroke, 37: 2601-2606, 2006.

• *H Su, Y Huang, J Takagawa, A Barcena, J Arakawa-Hoyt, J Ye, W Grossman and YW Kan. AAV Serotype-1 Mediates Early Onset of Gene Expression in Mouse Hearts and Results in better Therapeutic Effect. Gene Therapy, 13(21): 1495-502, 2006. (*corresponding author)

• F Shen, H Su, Y Fan, Y Zhu, Y Chen, YW Kan, WL Young, and GY Yang. Recombinant Adeno-Associated Viral Vector Encoding Human VEGF165 Induces Neomicrovessel Formation in the Adult Mouse Brain. Frontiers Bioscience, Sep 1;11:3190-8, 2006.

• *H Su, S Joho, Y Huang, A Barcena, J Arakawa-Hoyt, W Grossman and YW Kan. Adeno-Associated Viral Vector Delivers Cardiac-Specific and Hypoxia-Inducible VEGF Expression in Ischemic Mouse Hearts. Proc Natl Acad Sci USA, 101:16280-16285, 2004. (*corresponding author).

• DS Chang, H Su, GL Tang, LS Brevetti, R Sarkar, R Wang, YW Kan and LM Messina. Adeno-Associated Viral Vector Mediated Gene Transfer of Vascular Endothelial Growth Factor Normalizes Skeletal Muscle Oxygen Tension and Induces Arteriogenesis in Ischemic Rat Hindlimb. Molecular Therapy, 7:44-51, 2003

• H Su, J Arakawa-Hoyt and YW Kan. Adeno-Associated Viral Vector Mediated Hypoxia Response Element Regulated Gene Expression in Mouse Ischemic Heart Model. Proc Natl Acad Sci USA, 99:9480-9485, 2002.

• H Ruan, H Su, L Hu, KR Lamborn, YW Kan and DF Deen. A Hypoxia-Regulated Adeno-Associated Virus Vector for Cancer-Specific Gene Therapy. Neoplasia, 3(3): 1-9, 2001.

• H Su, R. Lu and Y. W. Kan: Adeno-Associated Viral Vector (AAV) Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Induces Formation in Ischemic Heart. Proc Natl Acad Sci USA, 97: 13801-13806, 2000.

• H Su, R Lu, R Ding and YW Kan. Adeno-Associated Viral-Mediated Gene Transfer to Hepatoma: Thymidine Kinase/Interleukin 2 is more Effective in Tumor Killing in Non-Ganciclovir (GCV)-Treated Than in GCV-Treated Animals. Molecular Therapy, 1(6): 509-515, 2000.

• H Su, R Lu, JC Chang and YW Kan. Tissue-Specific Expression of Herpes Simplex Virus Thymidine Kinase Gene Delivered by Adeno-Associated Virus Inhibits the Growth of Human Hepatocellular Carcinoma in Athymic Mice. Proc. Natl. Acad. Sci. USA, 94: 13981-13896, 1997.

• JD Liou, YY Ma, LH Gibson, H Su, N Charest, YF Lau and TL Yang-Feng. Cytogenetic and Molecular Studies of a Familial Paracentric inversion of Y Chromosome Present in a Patient with Ambiguous Genitalia. American Journal of Medical Genetics, 70(2):134-7, 1997.

• YW Kan, N Kasahara, A Dozy, C Wong, X Han and H Su. Tissue-Specific Gene Delivery and Gene Expression. J Clin Biochem Nutr, 21:80-81, 1996

• H Su, JC Chang, SM Xu, and YW Kan. Selective Killing of AFP-Positive Hepatocellular Carcinoma Cells by Adeno-Associated Virus Transfer of the Herpes Simplex Virus Thymidine Kinase Gene. Human Gene Therapy, 7: 463-470, (1996)

• H Su and Y-FC Lau. Identification of the Transcriptional Unit, Structural Organization and Promoter Sequence of the Human Sex Determining Region Y (SRY) Gene Using a Reverse Genetic Approach. Am. J Hum. Genet., 52:24-38, 1993.