Yongmei Chen, MD, PhD

Assistant Researcher

UCSF Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
San Francisco, CA 94110
phone: 415-206-4795
fax: 415-206-8907
email: meichen@anesthesia.ucsf.edu

Education and Training

• PhD, Neuroscience, University of Missouri-Columbia, Columbia, Missouri
• MD, Medicine, Hunan Medical University, Hunan, China

Research Interests

• Mechanisms underlying neurovascular remodeling
• Novel strategies for promoting neural repair after stroke injury
• Signaling pathways involved in vascular dysfunction

Research Funding

• R03 NS067507, NIH/NINDS 09/15/2009 – 08/31/2011
  Title: Endothelial progenitor cells in brain vascular dysfunction
  Role: Principal investigator

• R21 NS 053943, NIH/NINDS 05/01/2006-10/31/2008
  Title: Del-1 induces therapeutic cerebral angiogenesis
  Role: Principal investigator

• Beginning Grant-in-Aid, American Heart Association 07/01/2008-06/30/2010
  Title: Netrin-1 in Neurovascular Regeneration
  Role: Principal investigator

• F32 NS11044, NIH/NINDS 02/01/2000-03/31/2003
  Title: The physiological function of neuronal glutamate transporter EAAT3
  

Selected Publications

• Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y: IGF-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke, 39:1254-61, 2008

• Zhu W, Khachi S, Hao Q, Young WL, Yang GY, Chen Y: Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem Int, 52:1086-91, 2008

• Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y: Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res, 1219:1-7, 2008

• Chen Y., Zhu W, Bollen AW, Lawton MT, Barbaro NM, Dowd CF, Hashimoto T, Yang GY, Young WL: Evidence for inflammatory cell involvement in brain arteriovenous malformations. Neurosurgery, 62:1340-1350, 2008

• Fan Y, Shen F, Hao Q, Chen Y, Liu W, Su H, Young WL, Yang GY: Overexpression of Netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab, 28:90-98, 2008

• Fan Y, Ye J, Shen F, Zhu W, Zhu Y, Yeghiazarians Y, Chen Y, Lawton MT, Young WL, Yang GY: Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab, 28:90-98, 2008

• Chen Y., Fan Y, Poon KY, Achrol AS, Lawton MT, Zhu Y, McCulloch CE, Hashimoto T, Lee C, Barbaro NM, Bollen AW, Yang GY, and Young WL: MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Frontiers in Bioscience, 11:3121-3128, 2006

• Chen Y., Pawlikowska L, Yao JS, Shen F, Zhai W, Achrol AS, Lawton MT, Kwok PY, Yang GY, Young WL: Interleukin-6 involvement in brain arteriovenous malformations. Annals of Neurology, 59:72-80, 2006

• Chen Y., Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY: Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. J Cereb Blood Flow Metab. 24:1280-7, 2004

• Chen Y., and Swanson RA. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem, 84:1332-1339, 2003

• Chen Y., and Swanson RA. Astrocytes and brain injury. J Cereb Blood Flow Metab (Review), 23:137-149, 2003

• Chen Y., Vartiainen NE., Ying W., Chan PH., Koistinaho J., Swanson RA. Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem. 77:1601-1610, 2001

• Chen Y., Chan PH., Swanson RA. Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury. Glia. 33:343-34, 2000

• Chen Y., Ying W., Simma V., Copin J-C., Chan PH., Swanson RA. Overexpression of Cu,Zn superoxide dismutase attenuates oxidative inhibition of astrocyte glutamate uptake. J Neurochem. 75:939-945, 2000

• Chen Y., and Sun AY. Activation of AP-1 transcription factor after extracellular ATP treatment in PC12 cells. Neurochem Res. 23: 543-550, 1998

• Sun AY., Chen Y. Oxidative stress and neurodegenerative disorders. J Biomed Sci (Review) 5: 401-414, 1998

• Sun AY., Chen Y., and Wixom P. Ethanol enhanced lipid peroxidation and cell death in PC12 cells. Neurochem Res. 22:1187-1192, 1997

• Chen Y., Wixom P., and Sun AY. Enhanced (Na+K)-ATPase activity and expression in mouse brain after chronic ethanol administration. Neurochem Res. 22: 583-588, 1997