Helen Kim, Ph.D.

Assistant Professor, Department of Anesthesia & Perioperative Care

Faculty Member, UCSF Institute for Human Genetics

San Francisco General Hospital
Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
Building 10, 2nd Floor, Room 1206
San Francisco, CA 94110
phone: 415-206-4789
fax: 415-206-8907
email: kimhel@anesthesia.ucsf.edu

Education and Training

• MPH, Epidemiology, Emory University, Atlanta GA
• Ph.D., Epidemiology, University of Washington, Seattle, WA
• Postdoctoral Fellow, Genetic Epidemiology, University of Washington, Seattle, WA

Research Interests

• Genetic epidemiology of cardiovascular and neurological diseases, and in particular stroke
• Epidemiology and natural history of brain vascular malformations, including AVM and aneurysms
• Functional outcome after brain injury from intracranial hemorrhage or treatment
• Linkage and association studies of complex diseases and intermediate phenotypes
• Methods for detecting and adjusting for population stratification, and evaluating interactions

Selected Publications

• Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff J, Sidney S, Ko NU, Lawton MT, McCulloch CE, Kwok P-Y, Young WL. Common variants in interleukin-1-beta (IL-1B) gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cerebrovasc Dis 2009; 27:176-182.

• Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL. Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl. 2008;105:199-206. PMID: 19066109

• Kim H, Hysi PG, Pawlikowska L, McCulloch CE, Choudhry S, Kwok P-Y, Burchard EG, Young WL. Population stratification in a case-control study of brain arteriovenous malformation (BAVM) among Latinos. Neuroepidemiol 2008;31:224-228. PMID: 18841030

• Edwards KL, Hutter CM, Yin Wan J, Kim H, Monks. Genome-wide Linkage Scan for the Metabolic Syndrome: The GENNID Study. Obesity (Silver Spring), Apr/17/2008;16(7):1596-1601. PMID: 18421265

• Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL. Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke Apr/2008;39(4):1103-8. PMID: 18309169

• Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL. Feasibility of Minocycline and Doxycycline Use as Potential Vasculostatic Therapy for Brain Vascular Malformations: Pilot Study of Adverse Events and Tolerance. Cerebrovasc Dis, Jan/23/2008;25(1-2):157-163. PMID: 18212521

• Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johngston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL. Racial/ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Stroke 2007; 38:2430-2437. PMID: 17673729

• Achrol AS, Kim H, Pawlikowska L, Hysi P, Johnston SC, McCulloch CE, McDermott MW, Lawton ML, Kwok P-Y, Young WL. Association of tumor necrosis factor-alpha-238G>A and Apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurg Oct/2007;61(4):731-9. PMID: 17986934

• Young WL, Kwok P-Y, Pawlikowska L, Lawton MT, Kim H, Hysi PG, Marchuk DA. Arteriovenous malformation (letter). J Neurosurg 2007; 106(4):731-32.

• Kim H, Hutter CM, Monks SA, Edwards KL. Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: The Collaborative Study on the Genetics of Alcoholism. BMC Genet 2005 Dec 30;6 Suppl 1:S5. PMID: 16451661

• Dreisbach AW, Japa S, Sigel A, Parenti MB, Hess AE, Srinouanprachanh SL, Rettie AE, Kim H, Farin FM, Hamm LL, Lertora JJ. The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. Am J Hypertens 2005;18(10):1276-81.

• Kim H, Friedlander Y, Longstreth WT, Jr., Edwards KL, Schwartz SM, Siscovick DS. Family history as a risk factor for stroke in young women. Am J Prev Med 2004 Dec;27(5):391-396. PMID: 15556739

• Goode EL, Badzioch MD, Kim H, Gagnon F, Rozek LS, Edwards KL, Jarvik GP. Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study. BMC Genetics 2003;4(S1):S102. http://www.biomedcentral.com/1471-2156/4/s1/S102.

• Harrison T, Hindorff LA, Kim H, Wines RCM, Bowen DJ, McGrath BB, Edwards KL. Family history of diabetes as a potential public health tool. Am J Prev Med 2003;24(2):152-9. PMID: 12568821

• Kim H, Marcovina SM, Edwards KL, McKnight B, Bradley CM, McNeely MJ, Psaty BM, Motulsky AG, Austin MA. Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality in kindreds with familial combined hyperlipidemia or familial hypertriglyceridemia. Clin Genet2001;60(3):188-197. PMID: 11595020

• Kim H, Gearing M, Mirra SS. Ubiquitin immunoreactive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Neurology 1995;45:1768-1770.