Ludmila Pawlikowska, Ph.D.

Assistant Professor

Department of Anesthesia & Perioperative Care
San Francisco General Hospital
1001 Potrero Avenue, Box-1371
San Francisco, CA 94110
phone: 415-206-8906
fax: 415-206-8907

Institute for Human Genetics
University of California - San Francisco
513 Parnassus Ave, HSW 901A, Box 0793
San Francisco, CA 94143-0793
phone: (415)514-3880 or 514-3879
fax: (415) 476-2956
email: pawlikowskal@anesthesia.ucsf.edu

Education and Training

• Ph.D. Biomedical Sciences, UCSF
• Postdoctoral training: Liver Center, Cardiovascular Research Institute and Institute for Human Genetics, UCSF

Research Interests

• genetic studies of complex disease including brain arteriovenous malformation and subarachnoid hemorrhage
• genetic studies of human longevity and aging-related phenotypes
• admixture mapping of metabolic syndrome traits and inflammatory markers in admixed populations
• molecular genetics of inherited cholestasis

Selected Publications

• Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Reiner A, Atzmon G, Barzilai N, Psaty B, Hsueh WC, Cummings S, Browner W, Kwok PW, Ziv E. Association of common genetic variation in the insulin/IGF1 signaling pathway with human lifespan. Aging Cell 2009, in press.

• Nalls M A, Scherer M, Pawlikowska L, Ziv E, Mitchell G, Huntsman S, Sutton-Tyrrell K, Lakatta E, Hsueh WC, Newman A B, Tandon A, Kim L, Rongling Li, Patterson N, Psaty B, Reich D, Reiner A P, and Harris T. Admixture Mapping of Ankle-Arm Index: Identification of Candidate Locus Associated with Peripheral Arterial Disease. J Med Genet 2009, in press.

• Cheng C-Y, Kao WHL, Patterson N, Tandon A, Haiman CA, Harris TB, Xing C, John EM, Ambrosone CB, Brancati FL, Coresh J, Press MF, Parekh RS, Klag MJ, Meoni LA, Hsueh W-C, Fejerman L, Pawlikowska L, Freedman ML, Jandorf LH, Bandera EV, Ciupak GL, Nalls MA, Akylbekova EL, Orwoll ES, Leak TS, Miljkovic I, Li R, Ursin G, Bernstein L, Ardlie K, Taylor HA, Boerwinckle E, Zmuda JM, Henderson BE, Wilson JG, Reich D. Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. PLoS Genet. 2009, 5(5):e1000490.

• Hu D, Pawlikowska L, Kanaya A, Hsueh WC, Colbert L, Newman A, Satterfield S, Rosen C, Cummings S, Harris TB, Ziv E. Serum IGF-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study. J Am Geriat Soc 2009, in press.

• Walston JD , Matteini AM, Nievergelt C, Lange LA, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, LaCroix A, Tracy RP, Atzmon G, Lange EM and Reiner AP. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp Geront 2009 44(5):350-5.

• Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok P-Y, Young WL. Common variants in interleukin-1-beta (IL-1b) gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. Cerebrovascular Diseases 2008, 27(2):176-182.

• Kim H, Hysi PG, Pawlikowska L, Choudhry S, Burchard EG, Kwok PY, Sidney S, McCulloch CE, Kwok PY, Young WL. Population stratification in a case-control study of brain arteriovenous malformation (BAVM) in Latinos. Neuroepidemiology 2008, 31:224-228.

• Tseng ZH, Aouizerat B, Pawlikowska L, Vittinghoff E, Lin F, Whiteman D, Poon A, Herrington D, Howard T, Varosy PD, Hulley S, Malloy M, Kane J, Kwok P-Y, Olgin JE. Common ß Adrenergic Receptor Polymorphisms Are Not Associated with Risk of Sudden Cardiac Death in Patients with Coronary Artery Disease. Heart Rhythm 2008, 5(6):814-21.

• Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerová D, Rayner A, Dutton A, Meier Y, Antoniou A, Stieger B, Arnell H, Özçay F, Al-Hussaini HF, Bassas AF, Verkade HJ, Fischler B, Németh A, Kotalová R, Shneider BL, Cielecka-Kuszyk J, McClean P, Whitington PF, Sokal E, Jirsa M, Wali S, Jankowska I, Pawlowska J, Mieli-Vergani G, Knisely AS, Bull LN, Thompson RJ. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 108 ethnically diverse families. Gastroenterology 2008, 134(4):1203-14.

• Ko NU, Rajendren R, Kim H, Rutkowski M, Pawlikowska L, Kwok P-Y, Higashida RT, Lawton MT, Smith W, Zaroff JG, Young WL. Endothelial nitric oxide synthase polymorphisms and risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008, 39,1103-8.

• Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE. Interleukin-6 levels in atrial fibrillation: A cross-sectional analysis from the heart and soul study. American Heart Journal 2008, 155, 303-309.

• The International HapMap Consortium*. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007, 449, 851-861. (*see article for complete author list).

• The International HapMap Consortium*. Genome-wide detection and characterization of positive selection in human populations. Nature 2007, 449, 913-8. (*see article for complete author list).

• Achrol A.S., Kim H., Pawlikowska L., Poon K.Y., McCulloch C.E., Ko N., Johnston S.C., McDermott, M.W., Zaroff J.G., Lawton M.T., Kwok P.-Y., Young W.L. Association of Tumor Necrosis Factor-alpha 238G>A and Apolipoprotein E2 Polymorphisms with Intracranial Hemorrhage after Brain Arteriovenous Malformation Treatment. Neurosurgery 2007, 61(4), 731-9.

• Tingley W.G., Pawlikowska L., Zaroff J.G., Kim T., Nguyen T., Young S.G., Vranizan K., Kwok P.-Y., Whooley M.A. and Conklin B.R. Gene trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. PNAS 2007,104, 8461-8466.

• Reich D., Patterson N., Ramesh V., De Jager P.L., McDonald G.J., Tandon A., Choy E., Hu D., Tamraz B., Pawlikowska L., Wassel-Fyr C., Huntsman S., Waliszewska A., Rossin E., Li R., Garcia M., Reiner A., Ferrell R., Cummings S., Kwok P.Y., Harris T., Zmuda J.M. and Ziv E. for the Health ABC Study. Admixture mapping of an allele affecting soluble IL6 receptor and IL6 levels. American Journal of Human Genetics 2007, 80, 716-26.

• Knisely A.S., Strautnieks S.S., Meier Y., Stieger B., Byrne J.A., Portmann B.C., Bull L.N., Pawlikowska L., Bilezikçi B., Özçay F., László A., Tiszlavicz L., Moore L., Raftos J., Arnell H., Fischler B., Németh A., Papadogiannakis N., Cielecka-Kuszyk J., Jankowska I., Paw˝owska J., Melín-Aldana H., Emerick K.M., Whitington P.F., Mieli-Vergani G., Thompson R.J. Hepatocellular carcinoma in ten children under five years old with bile salt export pump deficiency. Hepatology 2006, 44, 478-86.

• Zaroff J.G., Pawlikowska L., Miss J.C., Yarlagadda S., Ha C., Achrol A., Kwok P.-Y., McCulloch C.E., Lawton M.T., Ko N., Smith W., Young W.L. Adrenoceptor Polymorphisms and the Risk of Cardiac Injury and Dysfunction After Subarachnoid Hemorrhage. Stroke 2006, 37, 1680-1685.

• Paulusma C.C., Groen A., Kunne C., Mok K., Spijkerboer A., de Waart D.R., Hoek F., Vreeling H., Hoeben K.A., van Marle J., Pawlikowska L., Bull L.N., Hofmann A.F., Knisely A.S., & Ronald P.J. Oude Elferink. ATP8B1 deficiency reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology 2006, 44, 195-2004.

• Pawlikowska L., Poon T., Ko N., Achrol A.S., McCulloch C.E., Ha C., Lum, K., Zaroff J.G., Johnston S.C., Lee C., Lawton M.T., Sidney S.X., Kwok P.-Y., Young W.L.; for the UCSF BAVM Study Project. ApoE e2 Associated with New Hemorrhage Risk in Brain Arteriovenous Malformation. Neurosurgery 2006, 58(5):838-43.

• Achrol A.S., Pawlikowska L., McCulloch C.E., Poon T., Ha C., Zaroff J.G., Johnston S.C., Lee C., Lawton M.T., Sidney S.X., Marchuk D.A, Kwok P.-Y., Young W.L.; for the UCSF BAVM Study Project. TNFA-238G>A Promoter Polymorphism is Associated with Increased Risk of New Hemorrhage in the Natural Course of Patients with Brain Arteriovenous Malformations. Stroke 2006, 37, 231-234.

• Chen Y., Pawlikowska L., Yao J.S., Shen F., Zhai W., Achrol A.S., Lawton M.T., Kwok P.-Y., Yang G.Y., and Young W.L. Interleukin-6 Involvement in Brain Arteriovenous Malformations. Annals of Neurology 2006, 59. 72-80.

• Altshuler D., Brooks L.D., Chakravarti A., Collins F.S., Daly M.J., Donnelly P.; International HapMap Consortium*. A haplotype map of the human genome. Nature 2005, 437, 1299-320 (*see article for author list).

• Pawlikowska L., Tran M., Achrol A.S., Ha C., Choudhry S., Burchard E.G., Castro R.A., Zaroff J.G., Lawton M.T., McCulloch C.E., Marchuk D.A, Kwok P.-Y, Young W.L. Genetic polymorphisms in endoglin and ALK-1 are associated with sporadic brain arteriovenous malformations. Stroke 2005, 36, 2278-2280.

• Carlton, V.E.H., Pawlikowska L. and Bull L.N. Molecular Basis of Intrahepatic Cholestasis. Annals of Medicine 2004, 36, 606-617.

• Pawlikowska L., Tran M., Achrol A., McCulloch C.E., Ha C., Lind D.L., Hashimoto T., Zaroff J., Lawton M.T., Marchuk D., Kwok P.Y., Young, W.L. and the UCSF BAVM study project. Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. Stroke 2004, 35, 2294-99.

• Klomp L.W.J., Vargas J.C., van Mil S.W.C., Pawlikowska L., Strautnieks S.S., van Eijk M.J.T., Juijn J.A., Pabon-Pena C., Smith L.B., DeYoung J.A., Byrne J.A, Gombert J., van der Brugge G., Berger R., Jankowska I., Pawlowska J., Knisely A.S., Thompson R.J., Freimer N.B., Houwen R.H.J. and Bull L.N. Characterization of mutations in ATP8B1 associated with hereditary cholestasis. Hepatology 2004, 40, 27-38.

• Pawlikowska L., Groen A., Eppens E.F., Kunne C., Ottenhoff R., Looije N., Knisely A.S., Killeen N.P., Bull, L.N., Oude Elferink R.P. and Freimer, N.B. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Human Molecular Genetics 2004, 13, 881-92.

• Bull L.N., van Eijk M.J.T., Pawlikowska L., DeYoung J., Juijn J.A., Liao M., Klomp L.W.J., Lomri N., Berger R., Scharschmidt B.F., Knisely A., Houwen R.H.J and Freimer N.B. Identification of a P-type ATPase mutated in two forms of hereditary cholestasis. Nature Genetics 1998, 18, 219-224.