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Hua Su, MD
Associate Professor
San Francisco General Hospital
Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
Building 10, 2nd Floor, Room 1206
San Francisco, CA 94110
phone: 415-206-3162
fax: 415-206-8907
email: hua.su@ucsf.edu
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Education and Training
- MD, Medicine, Nanjing Medical University, Nanjing, China
- MS, Histology and Embryology, Xian Medical University, Xian, China
- Postdoctoral Fellow, Reproductive Physiology, Beijing Medical University, Beijing, China
- Postdoctoral Fellow, Medical Genetics, University of California, San Francisco, CA
Research Interests
- Viral vector mediated targeted gene expression
- Gene and cell based therapies for ischemic heart disease
- Gene and cell based therapies for cerebral vascular diseases
- Development of rodent arteriovenous malformation model
Selected Publications
- Y Chen, Q Hao, H Kim, H Su, M Letarte, SA Karumanchi, MT Lawton, NM Barbaro, GY Yang, and WL Young: Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol, 66:19-27, 2009
- P Gao, Y Zhu, F Ling, F Shen, B Lee, RA Gabriel, Q Hao, GY Yang, *H Su, and WL Young: Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage via HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab, 29:1482-1490, 2009
- *H Su, J Takagawa, Y Huang, J Arakawa-Hoyt, J Pons, W Grossman and YW Kan. Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart. Int J Cardio, 133:191-197, 2009
- H Su, Q Hao, F Shen, Y Zhu, CZ Lee, WL Young, and GY Yang: Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl, 105:185-189, 2008
- Q Hao, J Liu, R Pappu, H Su, R Rola, RA Gabriel, CZ Lee, WL Young, and GY Yang: Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol, 28:2151-2157, 2008
- J Pons, Y Huang, J Arakawa-Hoyt, D Washko, J Takagawa, J Ye, W Grossman and *H Su: VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun, 376:419-422, 2008
- H Su, Y Yeghiazarians, A Lee, Y Huang, J Arakawa-Hoyt, J Ye, G Orcino, W Grossman, and YW Kan: AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. J Gene Med, 10:33-41, 2008
- F Shen, Y Fan, H Su, Y Zhu, Y Chen, W Liu, WL Young and GY Yang. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Therapy, 15: 30-39, 2008
- F Shen, H Su, Y Fan, Q Zhu, W Liu, WL Young, and GY Yang. Adeno-Associated Viral Vector-Mediated Hypoxia-Response Element-Regulated Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury Following Focal Cerebral Ischemia in Mice. Stroke, 37: 2601-2606, 2006.
- *H Su, Y Huang, J Takagawa, A Barcena, J Arakawa-Hoyt, J Ye, W Grossman and YW Kan. AAV Serotype-1 Mediates Early Onset of Gene Expression in Mouse Hearts and Results in better Therapeutic Effect. Gene Therapy, 13(21): 1495-502, 2006. (*corresponding author)
- F Shen, H Su, Y Fan, Y Zhu, Y Chen, YW Kan, WL Young, and GY Yang. Recombinant Adeno-Associated Viral Vector Encoding Human VEGF165 Induces Neomicrovessel Formation in the Adult Mouse Brain. Frontiers Bioscience, Sep 1;11:3190-8, 2006.
- *H Su, S Joho, Y Huang, A Barcena, J Arakawa-Hoyt, W Grossman and YW Kan. Adeno-Associated Viral Vector Delivers Cardiac-Specific and Hypoxia-Inducible VEGF Expression in Ischemic Mouse Hearts. Proc Natl Acad Sci USA, 101:16280-16285, 2004.
- H Su, J Arakawa-Hoyt and YW Kan. Adeno-Associated Viral Vector Mediated Hypoxia Response Element Regulated Gene Expression in Mouse Ischemic Heart Model. Proc Natl Acad Sci USA, 99:9480-9485, 2002.
- H Su, R. Lu and Y. W. Kan: Adeno-Associated Viral Vector (AAV) Mediated Vascular Endothelial Growth Factor (VEGF) Gene Transfer Induces Formation in Ischemic Heart. Proc Natl Acad Sci USA, 97: 13801-13806, 2000.
*Corresponding author
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