Shantel Weinsheimer

Visiting Postdoctoral Scholar
American Stroke Association Bugher Fellow

San Francisco General Hospital
Center for Cerebrovascular Research
1001 Potrero Avenue, Box-1371
Building 10, 2nd Floor, Room 1206
San Francisco, CA 94110
phone: 415-206-4701
fax: 415-206-8907
email: weinsheimers@anesthesia.ucsf.edu

Education and Training

• MS, Basic Medical Sciences, Wayne State University School of Medicine, Detroit, MI
• PhD, Molecular Biology and Genetics, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI

Research Interests

• Genetic studies of complex cerebrovascular diseases including brain arteriovenous malformation (AVM) and intracranial aneurysm.

Selected Publications

• Weinsheimer S, Pawlikowska L, Brettman A, Mancuso MR, Kuhnert F, Kuo C, Sidney S, Young WL, Kim H. G protein-coupled receptor 124 (GPR124) gene polymorphisms and risk of brain arteriovenous malformations (Abstract). International Stroke Conference, San Diego, CA 2009.

• Weinsheimer S, Kim H, Pawlikowska L, Kwok PY, Sidney S, McCulloch CE, Young WL. Ephrin B4 Receptor (EPHB4) gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations (BAVM) (Abstract). American Society of Human Genetics 58th Annual Meeting, Philadelphia, PA, 2008

• Helgadottir A, Thorleifson G, Magnusson KP...Weinsheimer S..., et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet , 40:217-224, 2008.

• Anagli J, Abounit K, Stemmer P, Han Y, Allred L, Weinsheimer S, Movsisyan A, Seyfried D. Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain. Biochem Biophys Res Commun, 366:86-91, 2008

• Weinsheimer S, Goddard K, Parrado T, Qing L, Sinha M, Lebedeva E, Khusnutdinova E, Khusainova R, Ronkainen A, Niemela M, Jaaskelainen J, Sakovich V, Land S, Kuivaniemi H, Tromp G. Association of kallikrein gene polymorphisms with intracranial aneurysms. Stroke, 38:2670-2676, 2007

• Weinsheimer S, Lenk GM, van der Voet M, Land S, Ronkainen A, Alafuzoff I, Kuivaniemi H, Tromp G. Integration of expression profiles and genetic mapping data to identify candidate genes in intracranial aneurysm. Physiol Genomics, 32:45-57, 2007

• Lenk GM, Tromp G, Weinsheimer S, Gatalica Z, Berguer R, Kuivaniemi H. Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics 8:237, 2007

• Fayz B, Moldenhauer JS, Wang D, Zhao C, Yao B, Liu D, Weinsheimer S, Gardner L, Johnson A, Womble DD, Krawetz SA. LARALink: a web application for cytogenetic linkage analysis. Clin Genetics, 67:314-321, 2005

• Betts R, Weinsheimer S, Blouse GE, Anagli J. Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT. J Biol Chem, 278:7800-7809, 2003

• Seyfried DM, Veyna R, Han Y, Li K, Tang N, Betts RL, Weinsheimer S, Chopp M, Anagli J. A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia. Brain Research, 901:94-101, 2001