Guo-Yuan Yang, MD, PhD

Associate Director,
Med-X Research Institute

Shanghai JiaoTong University
1954 Hua Shan Road
Shanghai 200030, China
phone: 0086-21-62932359
fax: 0086-21-62932302
email: gyyang@sjtu.edu.cn

Research Interests

• Development of rodent brain vascular disease models including ischemia, hemorrhage, angiogenesis, and arteriovenous malformation

• Development of cell based gene therapy for central nervous system using circulating endothelial progenitor cells

• Study the cellular and molecular mechanisms of ischemic brain injury

• Study the relationship between ischemic brain injury and blood brain barrier disruption and angiogenesis in the adult brain

Selected Publications

• Shen F, Su H, Fan Y, Chen Y, Zhu YQ, Liu W, Young WL, and Yang GY: Adeno-Associated Viral Vector-Mediated Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury After Focal Cerebral Ischemia in Mice Stroke. 2006 Aug 31; [Epub ahead of print]

• Zeng J, Yang GY, Ying Y, Kelly M, Hirai K, Swanson RA, James TL, and Litt L. Pyruvate Improves Recovery after PARP-1 Associated Energy Failure induced by Oxidative Stress in Neonatal Rat Cerebrocortical Slices. J Cereb Blood Flow Metab 2006: PMID: 16736046 [PubMed - as supplied by publisher]

• Zhu Y, Lawton MT, Du R, Shwe Y, Chen Y, Shen F, Young WL, and Yang GY: Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension. Neurosurg. 2006;59(3):687-696

• Yao JS, Zhai W, Fan Y, Young WL, and Yang GY. A novel role for Interleukin-6 stimulation of HCSMC proliferation: up-regulation of KDR. J Cereb Blood Flow Metab 2006: MID: 16820800 [PubMed - as supplied by publisher]

• Chen Y, Fan Y, Poon KYT, Achrol AS, Lawton MT, Zhu YQ, McCulloch CE, Hashimoto T, Lee CH, Barbaro NM, Bollen AW, Yang GY, and Young WL: MMP-9 Expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Front Biosci. 2006;11:3121-3128

• Shen FX, Su H, Fan Y, Zhu YQ, Chen Y, Kan YW, Young WL, and Yang GY: Recombinant adeno-associated viral vector encoding human VEGF165 induces neo-microvessel formation in the adult mouse brain. Front Biosci. 2006;11:3190-3198

• Zhu Y, Shwe Y, Du R, Chen Y, Shen FX, Young WL, and Yang GY. Effects of angiopoietin-1 on vascular endothelial growth factor-induced angiogenesis in the mouse brain. Acta Neurochir. 2006;96:438-443

• Yao JS, Zhai W, Young WL, and Yang GY: Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9. BBRC. 2006: 21;342:1396-1404

• Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, and Young WL: Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab 2006;26(9):1157-1164

• Chen Y, Pawlikowska L, Yao JS, Shen FX, Zhai W, Achrol AS, Lawton MT, Kwok PY, Yang GY, and Young WL: Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol. 2006;59(1):72-80