Books Edited by CCR Members

Cottrell JE, Young WL, Editors: Cottrell and Young's Neuroanesthesia, 5th ed. Philadelphia, Mosby Elsevier, 2010

Miller RD, Eriksson LI, Fleischer LA, Wiener-Kronish JP, Young WL, Editors: Miller's Anesthesia, Vol 1 & 2. 7th ed. New York, Churchill Livingstone, 2010

Jin K, Yang GY, Co-Editors: Experimental Stroke, Bentham eBooks. Bentham Science Publishers, 2008

Miller RD, Fleischer LH, Johns RA, Savarese JJ, Wiener-Kronish J, Young WL, Editors: Miller's Anesthesia, Vol 1 & 2. 6th ed. New York, Churchill Livingstone, 2005

Batjer HH, Editor-in-Chief, Caplan LR, Friberg L, Greenlee RG, Jr., Kopitnik TA, Young WL, Associate Editors: Cerebrovascular Disease, Philadelphia, Lippincott-Raven, 1997


Selected Publications

2016
Zhang R, Zhu W, Su H. Vascular integrity in the pathogenesis of brain arteriovenous malformation. Acta Neurochir Suppl. 2016;121:29-35.

PubMed abstract

Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H. Integrin β8 deletion enhances vascular dysplasia and hemorrhage in the brain of adult Alk1 heterozygous mice. Transl Stroke Res. 2016 Jun 29.Epub ahead of print

PubMed abstract

Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H. Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Angiogenesis. 2016 Jun 20. (Epub ahead of print)

PubMed abstract

Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016 Aug;22(4):445-451.

PubMed abstract

Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Bone fracture pre-ischemic stroke exacerbates ischemic cerebral injury in mice. PLoS One. 2016 Apr 18;11(4):e0153835.

PubMed abstract

Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T. Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages. Clin Neuropathol. 2016 Apr 6. 2016 May-Jun;35(3):114-121.

PubMed abstract

Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Lesion location, stability, and pre-treatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2016 May; 8(5):466-470

PubMed abstract

Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF. Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Free Radic Biol Med. 2016 Mar; 92:100-109

PubMed abstract

Weinsheimer S, Bendjilali N, Nelson J, Guo DE, Zaroff JG, Sidney S, McCulloch CE, Al-Shahi Salman R, Berg JN, Koeleman BP, Simon M, Bostroem A, Fontanella M, Sturiale CL, Pola R, Puca R, Lawton MT, Young WL, Pawlikowska L, Klijn CJ, Kim H. Genome-wide association study of sporadic brain arteriovenous malformations. J Neurol Neurosurg Psychiat. 2016 Sep;87(9):916-923.

PubMed abstract

2015
Choquet H, Pawlikowska L, Lawton MT, Kim H. Genetics of cerebral cavernous malformations: current status and future prospects. J Neurosurg Sci. 2015 Sep;59(3):211-220.

PubMed abstract

Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels. Biotechnol Rep (Amst). 2015 Sep;7:157-165.

PubMed abstract

Ma L, Guo Y, Zhao YL, Su H. The role of macrophage in the pathogenesis of brain arteriovenous malformation. Int J Hematol Res. 2015 Jan 1;1(2):52-56.

PubMed abstract

Lawton MT, Rutledge WC, Kim H, Stapf C, Whitehead KJ, Li DY, Krings T, terBrugge K, Kondziolka D, Morgan MK, Moon K, Spetzler RF. Brain arteriovenous malformations. Nat Rev Dis Prim. 2015 May 28;1:15008

PubMed abstract

Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Gene Ther. 2015 Nov;22(11):893-900.

PubMed abstract

Krings T, Kim H, Power S, Nelson J, Faughnan M, Young WL, TerBrugge KG. Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations. AJNR Am J Neuroradiol. 2015 May;36(5):863-870.

PubMed abstract

Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015 Jan;22(1):195-198.

PubMed abstract

Kim H, Nelson J, Krings T, terBrugge K, McCulloch CE, Lawton MT, Young WL, Faughnan ME. Hemorrhage rates from brain arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia. Stroke. 2015 May;46:1362-1364.

PubMed abstract

Abla AA, Nelson J, Kim H, Hess CP, Tihan T, Lawton MT. Silent arteriovenous malformation hemorrhage and the recognition of "unruptured" arteriovenous malformation patients who benefit from surgical intervention. Neurosurgery. 2015 May;76(5):592-600.

PubMed abstract

Abla AA, Rutledge WC, Seymour ZA, Guo D, Kim H, Gupta N, Sneed PK, Barani I, Larson D, McDermott MW, Lawton MT. A treatment paradigm for high-grade brain arteriovenous malformations: volume-staged radiosurgical downgrading followed by microsurgical resection. J Neurosurg. 2015 Feb;122(2):419-432.

PubMed abstract

Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res. 2015 Feb;6(1):50-59.

PubMed abstract

Kremer PH, Koeleman BP, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, Zaroff JG, Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA, Veldink JH, Kim H, Klijn CJ. Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. J Neurol Neurosurg Psychiat. 2015 May;86(5):524-529.

PubMed abstract

Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Young WL, Kim H, Faughnan ME. The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. Am J Med Genet A. 2015 Jun;167(6):1262-1267.

PubMed abstract

Alexander MD, Cooke DL, Nelson J, Guo DE, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H, Hetts SW. Association between venous angioarchitectural features of sporadic brain arteriovenous malformations and intracranial hemorrhage. AJNR Am J Neuroradiol. 2015 May;36(5):949-952.

PubMed abstract

Golden MJ, Morrison LA, Kim H, Hart BL. Increased number of white matter lesions in patients with familial cerebral cavernous malformations. AJNR Am J Neuroradiol. 2015 May;36(5):899-903.

PubMed abstract

Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, Stapleton C, Walcott BP, Ogilvy CS, Spetzler RF, Lawton MT. Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery. 2015 Jan;76(1):25-33.

PubMed abstract

Potts MB, Lau D, Abla A, Kim H, Young WL, Lawton MT. Current surgical results with low-grade brain arteriovenous malformations. J Neurosurg. 2015 Apr;122(4):912-920.

PubMed abstract

Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interven Neuroradiol. 2015 Feb;21(1):120-128.

PubMed abstract

Han SJ, Englot DJ, Kim H, Lawton MT. Brainstem arteriovenous malformations: anatomical subtypes, assessment of "occlusion in situ" technique, and microsurgical results. J Neurosurg. 2015 Jan;122(1):107-117.

PubMed abstract

Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosisn. J Vis Exp. 2015 Jan(95):e50472.

PubMed abstract

2014
Choquet H, Pawlikowska L, Nelson J, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H. Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity. Cerebrovas Dis. 2014 Dec 3;38(6):433-440.

PubMed abstract

Latino GA, Kim H, Nelson J, Pawlikowska L, Young WL, Faughnan ME. Severity score for Hereditary Hemorrhagic Telangiectasia. Orphanet J Rare Dis. 2014 Dec 29;9:188.

PubMed abstract

Abla AA, Nelson J, Rutledge WC, Young WL, Kim H, Lawton MT. The natural history of AVM hemorrhage in the posterior fossa: comparison of hematoma volumes and neurological outcomes in patients with ruptured infra- and supratentorial AVMs. Neurosurg Focus. 2015. 2014 Sep;37(3):E6.

PubMed abstract

Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H. Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation. Neuroimmunol Neuroinflamm. 2014;1(3):147-152.

PubMed abstract

Rutledge WC, Abla AA, Nelson J, Halbach VV, Kim H, Lawton MT. Treatment and outcomes of ARUBA eligible patients with unruptured brain arteriovenous malformations at a single institution. Neurosurg Focus. 2014 Sep;37(3):E8.

PubMed abstract

Han Z, Li L, Wang L, Degos V, Maze M, Su H. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Jul 10. 2014 Nov;131(4):498-508.

PubMed abstract

Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20;192PA:34-39.

PubMed abstract

Rutledge WC, Ko NU, Lawton MT, Kim H. Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations. Transl Stroke Res. 2014 Oct;5(5):538-542.

PubMed abstract

Kim H, Al-Shahi Salman R, McCulloch CE, Stapf C, Young WL. Untreated brain arteriovenous malformation: patient level meta-analysis of hemorrhage predictors. Neurology. 2014 Aug 12;83(7):590-597.

PubMed abstract

Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul;45(7):2101-2106.

PubMed abstract

Potts MB, Jahangiri A, Jen M, Sneed PK, McDermott MW, Gupta N, Hetts SW, Young WL, Lawton MT. Deep arteriovenous malformations in the basal ganglia, thalamus, and insula: multimodality management, patient selection, and results. World Neurosurg. 2014 September – October; 82(3-4):386-394.

PubMed abstract

Bendjilali N, Nelson J, Weinsheimer S, Sidney S, Zaroff JG, Hetts SW, Segal M, Pawlikowska L, McCulloch CE, Young WL, Kim H. Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms. J Neurol Neurosurg Psychiatry. 2014 Nov;85(11):1280-1283.

PubMed abstract

Chen W, Choi EJ, McDougall CM, Su H. Brain arteriovenous malformation modeling, pathogenesis and novel therapeutic targets. Transl Stroke Res. 2014 Jun;5(3):316-329.

PubMed abstract

Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H. De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation. Stroke. 2014 Mar;45(3):900-902.

PubMed abstract

Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One. 2014;9(2):e88511.

PubMed abstract

Choquet H, Nelson J, Pawlikowska L, McCulloch CE, Akers A, Baca B, Khan Y, Hart B, Morrison L, Kim H. Association of cardiovascular risk factors with disease severity in cerebral cavernous malformations type 1 subjects with the common Hispanic mutation. Cerebrovas Dis. 2014 Jan;37(1):57-63.

PubMed abstract

Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, Salman RA, Vicaut E, Young WL, Houdart E, Cordonnier C, Stefani MA, Hartmann A, von Kummer R, Biondi A, Berkefeld J, Klijn CJ, Harkness K, Libman R, Barreau X, Moskowitz AJ. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014 Feb 15;383(9917):614-621.

PubMed abstract

Chen W, Young WL, Su H. Induction of cerebrovascular malformation in the adult mouse. Methods Mol Biol. 2014;1135:309-316.

PubMed abstract

Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H. Influence of patient age on angioarchitecture of brain arteriovenous malformations. AJNR Am J Neuroradiol. 2014 Jul;35(7):1376-1380.

PubMed abstract

Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb;30(2):241-247.

PubMed abstract

2013
Potts MB, Young WL, Lawton MT. Deep arteriovenous malformations in the basal ganglia, thalamus, and insula: microsurgical management, techniques, and results. Neurosurgery. 2013 Sep;73(3):417-429.

PubMed abstract

Cooke D, Su H, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interven Neuroradiol. 2013. (in press)

PubMed abstract

Hasan DM, Chalouhi N, Jabbour P, Magnotta VA, Kung DK, Young WL. Imaging aspirin effect on macrophages in the wall of the human cerebral aneurysms using ferumoxytol-enhanced MRI: Preliminary results. J Neuroradiol. 2013 Jul;40(3):187-191.

PubMed abstract

Bendjilali N, Kim H, Weinsheimer S, Guo D, Kwok PY, Zaroff JG, Sidney S, Lawton MT, McCulloch CE, Koeleman BP, Klijn CJ, Young WL, Pawlikowska L. A genome-wide investigation of copy number variation in patients with sporadic brain arteriovenous malformation. PLoS One. 2013 Oct;8(10):e71434.

PubMed abstract

Gabarros Canals A, Rodriguez-Hernandez A, Young WL, Lawton MT. Temporal lobe arteriovenous malformations: anatomical subtypes, surgical strategy, and outcomes. J Neurosurg. 2013 Sep;119(3):616-628.

PubMed abstract

Akers AL, Ball KL, Clancy M, Comi AM, Faughnan ME, Gopal-Srivastava R, Jacobs TP, Kim H, Krischer J, Marchuk DA, McCulloch CE, Morrison L, Moses MA, Pawlikowska L, Young WL. Brain Vascular Malformation Consortium: Overview, progress and future directions. J Rare Disorders [Internet]. 2013 Apr;1(1):1-15.

PubMed abstract

Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun;118(6):1362-1372.

PubMed abstract

Degos V, Westbroek EM, Lawton MT, Hemphill JC III, del Zoppo GJ, Young WL. Perioperative management of coagulation in non-traumatic intracerebral hemorrhage. Anesthesiology. 2013 2013 Jul;119(1):218-227.

PubMed abstract

Hasan D, Chalouhi N, Jabbour PM, Dumont AS, Kung D, Magnotta V, Young WL, Hashimoto T, Winn HR, Hesitad D. Evidence that acetylsalicylic acid attenuates inflammation in the wall of human cerebral aneurysms: preliminary results. J Am Heart Assoc. 2013 Feb 22;2(1):e000019.

PubMed abstract

Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brainn. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):305-310.

PubMed abstract

Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Su H, Young WL. Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation. Stroke. 2013 Mar;44(3):795-798.

PubMed abstract

Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar;118(3):527-536.

PubMed abstract

Shen F, Kuo R, Milon-Camus M, Han Z, Jang L, Young WL, Su H. Intravenous delivery of AAV9 vector mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci. Stroke. 2013 Jan;44(1):252-254.

PubMed abstract

Boshuisen K, Brundel M, de Kovel CG, Letteboer TG, Rinkel GJ, Westermann CJ, Kim H, Pawlikowska L, Koeleman BP, Klijn CJ. Common polymorphisms in ACVRL1 and Endoglin genes are not associated with sporadic and HHT related brain arteriovenous malformations in Dutch patients. Transl Stroke Res. 2013 Jun;4(3):375-378.

PubMed abstract

2012
Hasan D, Chalouhi N, Jabbour P, Dumont AS, Kung DK, Magnotta VA, Young WL, Hashimoto T, Winn HR, Heistad D. Early change in ferumoxytol-enhanced magnetic resonance imaging signal suggests unstable human cerebral aneurysm. A pilot study. Stroke. 2012 Dec;43(12):3258-3265.

PubMed abstract

Rodriguez-Hernandez A, Kim H, Pourmohamad T, Young WL, Lawton MT. Cerebellar arteriovenous malformations: anatomical subtypes, surgical results, and increased predictive accurary of the supplementary grading system. Neurosurgery. 2012 Dec;71(6):1111-1124.

PubMed abstract

Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, terBrugge KG, White RI, Jr. Brain arteriovenous malformations associated with Hereditary Hemorrhagic Telangiectasia: genotype-phenotype correlations. Am J Med Genet. 2012 Nov;158(A)(11):2829-2834.

PubMed abstract

Weinsheimer S, Brettman A, Pawlikowska L, Mancuso MR, Kuhnert F, Lawton MT, Sidney S, Zaroff JG, McCulloch CE, Young WL, Kuo C, Kim H. G protein-coupled receptor 124 (GPR124) gene polymorphisms and risk of brain arteriovenous malformation. Transl Stroke Res. 2012 Dec;3(4):418-427.

PubMed abstract

Degos V, Gourraud PA, Trehel-Tursis V, Whelan R, Colonne C, Korinek AM, Clarencon F, Boch AL, Nouet A, Young WL, Apfel CC, Puybasset L. Elderly age as a prognostic marker of 1-year poor outcome for subarachnoid hemorrhage patients through its interaction with admission hydrocephalus. Anesthesiology. 2012 Dec;117(6):1289-1299.

PubMed abstract

Kim H, Pourmohamad T, Westbroek EM, McCulloch CE, Lawton MT, Young WL. Evaluating performance of the Spetzler-Martin supplemented model in selecting patients with arteriovenous malformation patients for surgery. Stroke. 2012 Sep;43(9):2497-2499.

PubMed abstract

Englot DJ, Young WL, Han SJ, McCulloch CE, Chang EF, Lawton MT. Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patients. Neurosurgery. 2012 Sep;71(3):572-580.

PubMed abstract

Westbroek EM, Pawlikowska L, Lawton MT, McCulloch CE, Young WL, Kim H. Brain-derived neurotrophic factor Val66Met polymorphism predicts worse functional outcome after surgery patients with unruptured brain arteriovenous malformation. Stroke. 2012 Aug;43(8):2255-2257.

PubMed abstract

Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue. NeuroReport. 2012 Jul;11;23(10):627-630.

PubMed abstract

Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA. The 4G/4G genotype of the PAI-1 (Serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012. Jul;12(7):1848-1854.

PubMed abstract

Wang DD, Englot DJ, Garcia PA, Chen T, Lawton MT, Young WL. Minocycline and tetracycline-class antibiotics protective against partial seizures in vivo. Epilepsy Res. 2012. Jul;43(7):1325-1330.

PubMed abstract

Walker EJ, Su H, Shen F, Degos V, Jun K, Young WL. Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain. Stroke. 2012. Jul;43(7):1325-1330.

PubMed abstract

Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL. Ferumoxytol-enhanced MRI to image inflammation within human brain arteriovenous malformations: a pilot investigation. Transl Stroke Res. 2012 Jul;3(Supplement 1):166-173.

PubMed abstract

Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H. Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse. Cerebrovasc Dis 2012 Jun;33(6):540-547.

PubMed abstract

Hasan DM, Mahaney KB, Magnotta VA, Kung DK, Lawton MT, Hashimoto T, Winn HR, Saloner D, Martin A, Gahramanov S, Dosa E, Neuwelt E, Young WL. Macrophage imaging within human cerebral aneurysms wall using ferumoxytol-enhanced MRI: a pilot study. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1032-1038.

PubMed abstract

Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL. Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Stroke. 2012 May;43(5):1240-1246.

PubMed abstract

Hetts SW, Keenan K, Fullerton H, Young WL, English JD, Gupta N, Dowd CF, Higashida RT, Lawton MT, Halbach VV: Pediatric intracranial non-galenic pial arteriovenous fistulas: clinical features, angioarchitecture, and outcomes. AJNR Am J Neuroradiol. 2012 Oct;33(9):1710-1719.

PubMed abstract

Degos V, Apfel CC, Sanchez P, Colonne C, Renuit I, Clarancon F, Nouet A, Boch AL, Pourmohamad T, Kim H, Gourraud PA, Young WL, Puybasset L: An admission bio-clinical score for coiled-aneurysm to predict 1-year outcomes. Stroke. 2012. May;43(5):1253-1259.

PubMed abstract

Alexander MJ, Hetts SW, Young WL, Halbach VV, Dowd CF, Higashida RT, English JD: Supernova hemorrhage: obliterative hemorrhage of brain arteriovenous malformations following gamma knife radiosurgery. J Neurointerv Surg. 2012 Sep 1;4(5):365-367.

PubMed abstract

Potts MB, Chang EF, Young WL, Lawton MT: Transsylvian-transinsular approaches to the insula and basal ganglia: operative techniques and results with vascular lesions. Neurosurgery. 2012 Apr;70(4):824-834.

PubMed abstract

Bharatha A, Faughnan ME, Kim H, Pourmohamad T, Krings T, Bayrak-Toydemir P, Pawlikowska L, McCulloch CE, Lawton MT, Dowd CF, Young WL, Terbrugge KG: Brain arteriovenous malformation multiplicity predicts the diagnosis of hereditary hemorrhagic telangiectasia: quantitative assessment. Stroke 2012 Jan;43(1):72-78.

PubMed abstract

Davies JM, Kim H, Young WL, Lawton MT: Classification schemes for arteriovenous malformations. Neurosurg Clin N Am. 2012 Jan;23(1):43-53.

PubMed abstract

Zaroff JG, Leong J, Kim H, Young WL, Cullen SP, Rao VA, Sorel M, Quesenberry CP, Jr., Sidney S: Cardiovascular predictors of long-term outcomes after non-traumatic subarachnoid hemorrhage. Neurocrit Care. 2012. Dec;17(3):374-381.

PubMed abstract

2011
Weinsheimer S, Xu H, Achrol AS, Stamova B, McCulloch CE, Pawlikowska L, Tian Y, Ko NU, Lawton MT, Steinberg GK, Chang SD, Jickling G, Ander BP, Kim H, Sharp FR, Young WL: Gene expression profiling of blood in brain arteriovenous malformation patients. Transl Stroke Res, 2:575-587, 2011.

PubMed abstract

Sun H, Le T, Tiffany TJ, Habib A, Wu S, Shen F, Young WL, Su H, Liu J: AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke. Neurobiol Dis, 44:73-83, 2011.

PubMed abstract

Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Mucke L, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M: Perioperative cognitive decline with the aging population. Mayo Clin Proc, 86:885-893, 2011.

PubMed abstract

Shen F, Walker EJ, Jiang L, Li J, Sun B, Heriyanto F, Young WL, Su H: Co-expression of angiopoietin1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. J Cereb Blood Flow Metab, 31:2343-2351, 2011.

PubMed abstract

Hoffmann A, Bredno J, Wendland MF, Derugin N, Hom J, Schuster T, Su H, Ohara PT, Young WL, Wintermark M: Validation of in vivo MRI blood-brain barrier permeability measurements by comparison with gold standard histology. Stroke, 42:2054-2060, 2011.

PubMed abstract

Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL: Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl, 111:83-92, 2011.)

PubMed abstract

Walker EJ, Shen F, Young WL, Su H: Cerebrovascular casting of adult mouse for 3D imaging and morphological analysis. J Vis Exp, 57:pii: 2958, 2011.

PubMed abstract

Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon S, Young WL, Su H: Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res, 2:366-375, 2011

PubMed abstract

Taub PR, Fields JD, Wu AH, Miss JC, Lawton MT, Smith WS, Young WL, Zaroff JG, Ko NU: Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhage. Neurocrit Care, 15:13-18, 2011.

PubMed abstract

Zhu Y, Wang A, Patel S, Kurpinski K, Diao E, Bao J, Kwong G, Young WL, Li S: Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration. Tissue Eng Part C Methods, 17:705-715, 2011

PubMed abstract

Su H, Yang GY: Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol, 686:429-446, 2011. PubMed abstract

Mikhak B, Weinsheimer S, Pawlikowska L, Poon A, Kwok PY, Lawton MT, Chen Y, Zaroff JG, Sidney S, McCulloch CE, Young WL, Kim H: Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations (BAVM). Cerebrovasc Dis, 31:338-345, 2011.

PubMed abstract

Monson KL, Matsumoto MM, Young WL, Manley GT, Hashimoto T: Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties. J Mech Behav Biomed Mater, 4:9-15, 2011

PubMed abstract

Hao Q, Su H, Palmer D, Sun B, Gao P, Yang GY, Young WL: Bone marrow-derived cells contribute to VEGF-induced angiogenesis in the adult mouse brain by supplying MMP-9. Stroke, 42:453-458, 2011.

PubMed abstract

Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T: Critical roles of macrophages in the formation of intracranial aneurysm. Stroke, 42:173-178, 2011.

PubMed abstract

Gabarros A, Young WL, McDermott MW, Lawton MT: Language and motor mapping during resection of brain arteriovenous malformations: indications, feasibility, and utility. Neurosurgery, 2011, 68:744-752, 2011.

PubMed abstract

Kim YB, Young WL, Lawton MT: Parafalcine and midline arteriovenous malformations: surgical strategy, techniques, and outcomes. J Neurosurg, 114:984-993, 2011.

PubMed abstract

Boussel L, Rayz V, Martin AJ, Lawton MT, Higashida RT, Smith WS, Young WL, Saloner D: Temporal stability of dysmorphic, fusiform aneurysms of the intra-cranial internal carotid artery. J Vasc Interv Radiol, 22:1007-1011, 2011.

PubMed abstract

Walker E, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL: Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol, 69:954-962, 2011.

PubMed abstract

2010
Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ: Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science, 330:985-989, 2010.

PubMed abstract

Logvinova A, Litt L, Young WL, Lee CZ: Anesthetic concerns in patients with known cerebrovascular insufficiency. Anesthesiol Clin, 28:1-12, 2010

PubMed abstract

Mohr JP, Moskowitz AJ, Stapf C, Hartmann A, Lord K, Marshall SM, Mast H, Moquete E, Moy CS, Parides M, Pile-Spellman J, Al-Shahi Salman R, Weinberg A, Young WL, Estevez A, Kureshi I, Brisman JL: The ARUBA trial current status, future hopes. Stroke, 41:e537-e540, 2010.

PubMed abstract

Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL: VEGF induces more severe cerebrovascular dysplasia in Endoglin+/- than in Alk1+/- mice. Transl Stroke Res, 1:197-201, 2010.

PubMed abstract

Delaloy C, Liu L, Lee J-A, Shen F, Su H, Yang GY, Young WL, Ivey KN, Gao FB: MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell, 6:323-335, 2010

PubMed abstract

Kim H, McCulloch CE, Johnston SC, Lawton MT, Sidney S, Young WL: Comparison of two approaches for determining the natural history risk of brain arteriovenous malformation rupture. Am J Epidemiol, 171:1317-1322, 2010.

PubMed abstract

Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL: Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations. Neurosurgery, 67:1029-1035, 2010.

PubMed abstract

Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY: Endothelial progenitor cell transplantation improves long-term outcome in mice. Ann Neurol, 67:488-497, 2010.

PubMed abstract

Lawton MT, Kim H, McCulloch CE, Mikhak B, Young WL: A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery. Neurosurgery, 2010. (in press)

PubMed abstract

Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol AS, Zaroff JG, Young WL: Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population. Stroke, 41:21-26, 2010.

PubMed abstract

Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL: Reduced expression of integrin {alpha}v{beta}8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol, 176:1018-1027, 2010.

PubMed abstract

2009
Potter CA, Armstrong-Wells J, Fullerton HJ, Young WL, Higashida RT, Dowd CF, Halbach VV, Hetts SW: Neonatal giant pial arteriovenous malformation: genesis or rapid enlargement in the third trimester. J NeuroIntervent Surg, 1:151-153, 2009.

PubMed abstract

Liu J, Segal M, Yoo S, Yang GY, Kelly M, James TL, Litt L: Antioxydant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. Neurochemistry Int,54:106-110, 2009

PubMed abstract

ZhuGe Q, Zhou M, Zheng W, Yang GY, Mao X, Xie L, Gourong C, Chen Y, Lawton MT, Young WL, Greenberg DA, Jin K: Notch1 signaling is activated in brain arteriovenous malformation in humans. Brain, 132:3231-3241, 2009.

PubMed abstract

Leblanc GG, Golanov E, Awad IA, Young WL: Biology of vascular malformations of the brain. Stroke, 40:e694-e702, 2009.

PubMed abstract

Weinsheimer S, Kim H, Pawlikowska L, Chen Y, Lawton MT, Sidney S, Kwok PY, McCulloch CE, Young WL: Ephrin receptor B4 (EPHB4) gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations. Circ Cardiovasc Genet, 2:476-482, 2009.

PubMed abstract

Gao P, Shen F, Gabriel RA, Law D, Yang E, Yang GY, Young WL, Su H: Attenuation of brain response to VEGF-mediated angiogenesis and neurogenesis in aged mice. Stroke, 40:3596-3600, 2009.

PubMed abstract

Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A, Hashimoto T: Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab, 29:1547-1558, 2009.

PubMed abstract

Zhu W, Fan Y, Hao Q, Shen F, Hashimoto T, Yang GY, Gasmi M, Bartus RT, Young WL, Chen Y: Post-ischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke. J Cereb Blood Flow Metab, 29:1528-1537, 2009.

PubMed abstract

Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL: Nonischemic cerebral venous hypertension promotes a pro-angiogenic state through HIF-1 downstream genes and leukocyte-derived MMP-9. J Cereb Blood Flow Metab, 29:1482-1490, 2009.

PubMed abstract

Sanchez-Mejia RO, McDermott MW, Tan J, Kim H, Young WL, Lawton MT: Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity. Neurosurgery, 64:231-238, 2009 PubMed abstract

Lee CZ, Xue Z, Hao Q, Yang GY, Young WL: Nitric oxide in vascular endothelial growth factor-induced focal angiogenesis and matrix metalloproteinase-9 activity in the mouse brain. Stroke, 40:2879-2881, 2009.

PubMed abstract

Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL: Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol, 66:19-27, 2009.

PubMed abstract

Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ: Restoring HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol, 68:626-632, 2009.

PubMed abstract

Boussel L, Rayz V, Martin AJ, Acevedo-Bolton G, Lawton MT, Higashida RT, Smith WS, Young WL, Saloner D: Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics. Magn Reson Med., 61:409-417, 2009

PubMed abstract

Kim H, Hysi PG, Pawlikowska L, Poon A, Burchard EG, Zaroff JG, Sidney S, Ko NU, Achrol AS, Lawton MT, McCulloch CE, Kwok PY, Young WL: Common variants in interleukin-1-beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation. J Cerebrovasc Dis, 27:176-182, 2009

PubMed abstract

Nuki Y, Matsumoto MM, Tsang E, Young WL, van Rooijen N, Kurihara C, Hashimoto T: Roles of macrophages in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab, 29:495-503, 2009

PubMed abstract

Kim H, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL: Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development. Stroke, 40[suppl 1]:S95-S97, 2009

PubMed abstract

2008
Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY: Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. Am J Physiol Heart Circ Physiol, 295:H2250-H2256, 2008

PubMed abstract

Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Young WL, Yang GY: The contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages. Arterioscler Thromb Vasc Biol, 28:2151-2157, 2008.

PubMed abstract

Rayz VL, Boussel L, Lawton MT, Acevedo-Bolton G, Ge L, Young W, Higashida RT, Saloner D: Numerical modeling of the flow in intracranial aneurysms: prediction of regions prone to thrombus formation. Ann Biomed Eng, 36:1793-1804, 2008.

PubMed abstract

Rayz VL, Boussel L, Acevedo-Bolton G, Martin AJ, Young WL, Lawton MT, Higashida R, Saloner D: Numerical simulations of flow in cerebral aneurysms: comparison of CFD results and in vivo MRI measurements. J Biomech Eng, 130:051011, 2008

PubMed abstract

Kim H, Hysi PG, Pawlikowska L, Choudhry S, Burchard EG, Kwok PY, Sidney S, McCulloch CE, Young WL: Population stratification in a case control study of brain arteriovenous malformation (BAVM) in Latinos. Neuroepidemiology, 31:224-228, 2008

PubMed abstract

Lawton MT, Arnold CM, Kim YJ, Bogarin EA, Stewart CL, Wulfstat AA, Derugin N, Deen D, Young WL: Radiation arteriopathy in the transgenic arteriovenous fistula model. Neurosurgery, 62:1129-1138

PubMed abstract

Fan Y, Zhu W, Yang M, Zhu Y, Shen F, Hao Q, Young WL, Yang GY, Chen Y: Del-1 gene transfer induces cerebral angiogenesis in mice. Brain Res, 1219:1-7, 2008

PubMed abstract

Su H, Hao Q, Shen F, Zhu Y, Lee CZ, Young WL, Yang GY: Development of cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl, 105:185-189, 2008.

PubMed abstract

Boussel L, Rayz V, McCulloch CE, Martin A, Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D: Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke, 39:2997-3002, 2008

PubMed abstract

Kim H, Marchuk DA, Chen Y, Su H, Yang GY, Young WL: Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations. Acta Neurochir Suppl, 105:199-206, 2008.

PubMed abstract

Fan Y, Shen F, Hao Q, Chen Y, Liu W, Su H, Young WL, Yang GY: Overexpression of Netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab, 28:1543-1551, 2008

PubMed abstract

Singh V, Smith WS, Lawton MT, Halbach VV, Young WL: Risk factors for hemorrhagic presentation in patients with dural arteriovenous fistulae. Neurosurgery, 62:628-635; discussion 628-635, 2008

PubMed abstract

Chen Y, Zhu W, Bollen AW, Lawton MT, Barbaro NM, Dowd CF, Hashimoto T, Yang GY, Young WL: Evidence for inflammatory cell involvement in brain arteriovenous malformations. Neurosurgery, 62:1340-1349; discussion 1349-1350, 2008, 2008

PubMed abstract

Zhu W, Khachi S, Hao Q, Shen F, Young WL, Yang GY, Chen Y: Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem Int, 52:1086-91, 2008

PubMed abstract

Shen F, Fan Y, SU H, Zhu Y, Chen Y, Liu W, Young WL, Yang GY: Adeno-associated viral vector-mediated hypoxia-regulated VEGF factor gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther, 15:30-39, 2008

PubMed abstract

Fan Y, Ye J, Shen F, Zhu W, Zhu Y, Yeghiazarians Y, Chen Y, Lawton MT, Young WL, Yang GY: Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab, 28:90-98, 2008

PubMed abstract

Zhu W, Fan Y, Frenzel T, Gasmi M, Bartus RT, Young WL, Yang GY, Chen Y: IGF-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke, 39:1254-61, 2008

PubMed abstract

Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL: Endothelial nitric oxide synthase polymorphisms (-786T>C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke, 39:1103-8, 2008

PubMed abstract

Zhu W, Tian Y, Zhou LF, Wang Y, Song D, Mao Y, Yang GY: Development of a novel endothelial cell-seeded endovascular stent for intracranial aneurysm therapy. J Biomed Mater Res A, 85:715-721, 2008

PubMed abstract

Rayz VL, Lawton MT, Martin AJ, Young WL, Saloner D: Numerical simulation of pre- and post-surgical flow in a giant basilar aneurysm. J Biomech Eng., 130:021004, 2008

PubMed abstract

Boussel L, Wintermark M, Martin AJ, Dispensa B, VanTijen R, Leach J, Rayz V, Acevedo-Bolton G, Lawton MT, Higashida RT, Smith WS, Young WL, Saloner D: Monitoring serial change in the lumen and outer wall of vertebro-basilar aneurysms. AJNR Am J Neuroradiol, 29:259-64, 2008

PubMed abstract

Frenzel T, Lee CZ, Kim H, Quinnine N, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL: Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance. Cerebrovasc Dis, 25:157-163, 2008

PubMed abstract

2007
Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L: Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology,107:630-640, 2007. PubMed abstract
Gabriel RA, Yang GY: Gene therapy in cerebrovascular diseases. Curr Gene Ther, 7:421-33, 2007 PubMed abstract
Achrol AS, Kim H, Pawlikowska L, Poon KYT, Ko NU, McCulloch CE, Zaroff JG, Johnston SC, McDermott MW, Lawton MT, Kwok PY, Young WL: Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment. Neurosurgery, 2007, 61:731-9; discussion 740, 2007 PubMed abstract
Hashi CK, Zhu Y, Yang GY, Young WL, Hsiao BS, Wang K, Chu B, Li S: Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proc Natl Acad Sci USA, 104:11915-20, 2007 PubMed abstract
Kim H, Sidney S, McCulloch CE, Poon KYT, Singh V, Johnston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL: Racial/ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Stroke, 38:2430-37, 2007 PubMed abstract
Lawton MT, Lu DC, Young WL: Sylvian fissure arteriovenous malformations: an application of the Sugita classification to 28 surgical patients. Neurosurgery 61:29-38, 2007 PubMed abstract
Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL: Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracranial hemorrhage. Stroke, 38:2563-68, 2007 PubMed abstract
Du R, Hashimoto T, Tihan T, Young WL, Perry V, Lawton MT: Growth and regression of an arteriovenous malformation in a patient with hereditary hemorrhagic telangiectasia: case report. J Neurosurg 106:470-7, 2007. PubMed abstract
Yao JS, Fan Y, Zhai W, Lawton MT, Barbaro NM, Young WL, Yang G-Y: Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells. J Cereb Blood Flow Metab 27:510-20, 2007. PubMed abstract
Yao JS, Shen F, Young WL, Yang G-Y: Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration. Neurochem Int 50:524-530, 2007. PubMed abstract
Hao Q, Chen Y, Zhu Y, Fan Y, Young WL, Yang GY: Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain. J Cereb Blood Flow Metab , 27:1853-60, 2007 PubMed abstract
Du R, Keyoung HM, Dowd CF, Young WL, Lawton MT: The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations. Neurosurgery 60:638-46, 2007. PubMed abstract
Dispensa BP, Saloner DA, Acevedo-Bolton G, Achrol, AS, Jou L-D, McCulloch CE, Higashida RT, Dowd CF, Halbach VV, Ko NU, Lawton MT, Martin AJ, Quinnine NJ, Young WL: Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging. J Magn Reson Imaging 26:177-83, 2007. PubMed abstract
2006
Pawlikowska L, Poon KYT, Achrol AS, McCulloch CE, Ha C, Lum K, Zaroff J, Ko NU, Johnston SC, Sidney S, Marchuk DA, Lawton MT, Kwok P-Y, Young WL: Apoliprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformation. Neurosurgery 58:838-43; discussion 838-43, 2006. PubMed abstract
Chen Y, Fan Y-F, Yao JS, Poon KYT, Achrol AS, Lawton MT, Zhu Y, McCulloch CE, Hashimoto T, Lee C, Barbaro NM, Bollen AW, Yang G-Y, Young WL: MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations. Front Biosci 11:3121-8, 2006. PubMed abstract
Acevedo-Bolton G, Jou LD, Dispensa BP, Lawton MT, Higashida RT, Martin AJ, Young WL, Saloner D: Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report. Neurosurgery 59:E429-30; author reply E429-30, 2006. PubMed abstract
Yarlaggada S, Rajendran P, Miss JC, Banki NM, Kopelnik A, Wu AHB, Ko NU, Gelb AW, Lawton MT, Smith WS, Young WL, Zaroff JG: Cardiovascular predictors of inpatient mortality after subarachnoid hemorrhage. Neurocrit Care 5:102-107, 2006. PubMed abstract
Zhu Y, Lawton MT, Du R, Shwe Y, Shen F, Young WL, Yang G-Y: Expression of hypoxia-inducible factor-1 and vascular endothelial growth factor in response to venous hypertension. Neurosurgery 59:687-696, 2006. PubMed abstract
Zhu Y, Shwe Y, Du R, Chen Y, Shen F, Young WL, Yang G-Y: Effects of angiopoietin-1 on the vascular endothelial growth factor-induced angiogenesis in the mouse brain Acta Neurochir Suppl 96:438-43, 2006. PubMed abstract
Zaroff JG, Pawlikowska L, Miss, JC, Yarlagadda, S, Ha C, Achrol AS, Kwok P-Y, McCulloch CE, Lawton, MT, Ko NU, Smith WS, Young WL: Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage. Stroke, 37:1680-1685, 2006. PubMed abstract
Shen F, Su H, Liu W, Kan YW, Young WL, Yang G-Y: Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci 11:3190-8, 2006. PubMed abstract
Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang G-Y: Adeno-associated viral vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury following focal cerebral ischemia in mice. Stroke 37:2601-6, 2006. PubMed abstract
Sanchez-Mejia RO, Chenaputi S, Nalin G, Fullerton HJ, Young WL, Lawton MT: Superior outcomes in children versus adults after microsurgical resection of brain arteriovenous malformations. J Neurosurg 105:82-7, 2006. PubMed abstract
Yao JS, Zhai W, Young WL, Yang GY. Related Articles, Links Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1396-404. PubMed abstract
Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Related Articles, Links Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. J Cereb Blood Flow Metab. 2006 Jan 4; PubMed abstract
Chen Y, Pawlikowska L, Yao JS, Shen F, Zhai W, Achrol AS, Lawton MT, Kwok PY, Yang GY, Young WL. Related Articles, Links Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol. 2006 Jan;59(1):72-80. PubMed abstract
Achrol AS, Pawlikowska L, McCulloch CE, Poon KY, Ha C, Zaroff JG, Johnston SC, Lee C, Lawton MT, Sidney S, Marchuk DA, Kwok PY, Young WL; UCSF BAVM Study Project. Related Articles, Links Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations. Stroke. 2006 Jan;37(1):231-4. PubMed abstract
2005
Pawlikowska L, Tran MN, Achrol AS, Ha C, Burchard E, Choudhry S, Zaroff J, Lawton MT, Castro R, McCulloch CE, Marchuk D, Kwok PY, Young WL; UCSF BAVM Study Project. Related Articles, Links Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations. Stroke. 2005 Oct;36(10):2278-80. PubMed abstract
Fullerton HJ, Achrol AS, Johnston SC, McCulloch CE, Higashida RT, Lawton MT, Sidney S, Young WL; UCSF BAVM Study Project. Related Articles, Links Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations. Stroke. 2005 Oct;36(10):2099-104. PubMed abstract
Zhu Y, Lee C, Shen F, Du R, Young WL, Yang GY. Related Articles, Links Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain. Stroke. 2005 Jul;36(7):1533-7. PubMed abstract
Hashimoto T, Wu Y, Lawton MT, Yang GY, Barbaro NM, Young WL: Coexpression of angiogenic factors in brain arteriovenous malformations. Neurosurgery. 2005 May;56(5):1058-65; discussion 1058-65 PubMed abstract
Ko NU, Achrol AS, Chopra M, Saha M, Gupta D, Smith WS, Higashida RT, Young WL: Cerebral blood flow changes after endovascular treatment of cerebrovascular stenoses. Am J Neuroradiol. 2005 Mar;26(3):538-42 PubMed abstract
Lawton MT, Du R, Tran MN, Achrol AS, McCulloch CE, Johnston SC, Quinnine NJ, Young WL: Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations. Neurosurgery. 2005 Mar;56(3):485-93 PubMed abstract
Ko NU, Achrol AS, Martin AJ, Chopra M, Saloner DA, Higashida RT, Young WL: Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting. Stroke. 2005 Mar;36(3):676-8 PubMed abstract
Hashimoto T, Matsumoto MM, Li JF, Lawton MT, Young WL: Suppression of MMP-9 by doxycycline in brain arteriovenous malformations. BMC Neurol. 2005 Jan 24;5(1):1 PubMed abstract
2004
Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY: Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. J Cereb Blood Flow Metab. 2004 Nov;24(11):1280-7 PubMed abstract
Young WL, Yang GY. Are there genetic influences on sporadic brain arteriovenous malformations? Stroke. 2004 Nov;35(11 Suppl 1):2740-5. Epub 2004 Oct 07 PubMed abstract
Pawlikowska L, Tran MN, Achrol AS, McCulloch CE, Ha C, Lind DL, Hashimoto T, Zaroff J, Lawton MT, Marchuk DA, Kwok PY, Young WL: UCSF BAVM Study Project. Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. Stroke. 2004 Oct;35(10):2294-300. Epub 2004 Aug 26 PubMed abstract
Hashimoto T, Wu Y, Boudreau N, Li J, Matsumoto M, Young W. : Regulation of Tie2 Expression by Angiopoietin-Potential Feedback System. Endothelium 2004;11(3-4):207-210 PubMed abstract
Yao JS, Chen Y, Zhai W, Xu K, Young WL, Yang GY. : Minocycle Exerts Multiple Inhibitory Effects on Vascular Endothelial Growth Factor-Induced Smooth Muscle Cell Migration. The Role of ERK1/2, PI3K, and Matrix Metalloproteinases. Circ Res. Jul 15 PubMed abstract
Lee CZ, Xu B, Hashimoto T, McCulloch CE, Yang GY, Young WL : Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke. 2004 Jul;35(7):1715-9. Epub 2004 May 27. PubMed abstract
Halim AX, Johnston SC, Singh V, McCulloch CE, Bennett JP, Achrol AS, Sidney S, Young WL. : Longitudinal risk of intracranial hemorrhage in patients with arteriovenous malformation of the brain within a defined population. Stroke. 2004 Jul;35(7):1697-702. PubMed abstract
Lawton MT, Stewart CL, Wulfstat AA, Derugin N, Hashimoto T, Young WL. : The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations. Neurosurgery. 2004 Jun;54(6):1463-71; discussion 1471. PubMed abstract
Kim EJ, Halim AX, Dowd CF, Lawton MT, Singh V, Bennett J, Young WL. : The relationship of coexisting extranidal aneurysms to intracranial hemorrhage in patients harboring brain arteriovenous malformations. Neurosurgery. 2004 Jun;54(6):1349-57; discussion 1357-8. PubMed abstract
Lee CZ, Litt L, Hashimoto T, Young WL. : Physiologic monitoring and anesthesia considerations in acute ischemic stroke. J Vasc Interv Radiol. 2004 Jan;15(1 Pt 2):S13-9. PubMed abstract
Yang GY, Yao JS, Huey M, Hashimoto T, Young WL: Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration. Neurochem Int. 44(6):441-6, May 2004 PubMed abstract
Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang GY: Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J Cereb Blood Flow Metab. 24(2): 237-244, February 2004 PubMed abstract
Hashimoto T, Lawton MT, Wen G, Yang GY, Chaly T JR, T, Stewart CL, Dressman HK, Barbaro NM, Marchuk DA, Young WL: Gene microarray analysis of human brain arteriovenous malformations. Neurosurgery 54(2): 410-425, February 2004 PubMed abstract
2003
Jou LD, Quick CM, Young WL, Lawton MT, Higashida R, Martin A, Saloner D. : Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. AJNR Am J Neuroradiol. 2003 Oct;24(9):1804-10. PubMed abstract
Yang, GY, Xu B, Hashimoto T, Huey M, Chaly Jr T, Wen R, and Young WL. Induction of focal angiogenesis through adenoviral vector mediated vascular endothelial cell growth factor gene transfer in the mature mouse brain. Angiogenesis. 6(2): 151-158, 2003 PubMed abstract
Huang FP, Wang ZQ, Wu DC, Schielke GP, Sun Y, Yang GY.: Early NFkappaB activation is inhibited during focal cerebral ischemia in interleukin-1beta-converting enzyme deficient mice. J Neurosci Res. 1;73(5):698-707, 2003 PubMed abstract
Ko NU, Johnston SC, Young WL, Singh V, Klatsky AL: Distinguishing intracerebral hemorrhages caused by arteriovenous malformations. Cerebrovasc Dis 15:206-9, 2003 PubMed abstract
Lawton MT: Spetzler-Martin Grade III arteriovenous malformations: surgical results and a modification of the grading scale. Neurosurgery 52:740-8; discussion 748-9, 2003 PubMed abstract
Hashimoto T, Wen G, Lawton MT, Boudreau N, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL: Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke 34:925-931, 2003 PubMed abstract
2002
Hashimoto T, Gupta DK, Young WL: Interventional neuroradiology--anesthetic considerations. Anesthesiol Clin North America, 20(2):347-59, vi, 2002 PubMed abstract
Quick CM, James DJ, Ning K, Joshi S, Halim AX, Hashimoto T, Young WL: Relationship of nidal vessel radius and wall thickness to brain arteriovenous malformation hemorrhage. Neurol Res, 24 (5):495-500, 2002 PubMed abstract
Hashimoto T, Young WL, Prohovnik I, Gupta DK, Ostapkovich ND, Ornstein E, Halim AX, Quick CM: Increased cerebral blood flow after brain arteriovenous malformation resection is substantially independent of changes in cardiac output. J Neurosurg Anesthesiol, 14 (3): 204-8, 2002 PubMed abstract
Halim AX, Young WL, Johnston SC: Reliability of angiographic assessment of brain arteriovenous malformations (editorial comment). Stroke 33 (6): 1508-9, 2002 PubMed abstract
Quick CM, Berger DS, Noordergraaf A: Pulse wave reflection as feedback in the arterial system. IEEE Trans. Biomed. Eng., 49: 440-445, 2002 PubMed abstract
Gupta DK, Young WL, Hashimoto T, Halim AX, Marshall RS, Lazar RM, Joshi S, Pile-Spellman J, Ostapkovich N: Characterization of the cerebral blood flow response to balloon deflation after temporary internal carotid artery test occlusion. J Neurosurg Anesthesiol, 14 (2):123-9, 2002 PubMed abstract
Halim AX, Singh V, Johnston SC, Higashida RT, Dowd CF, Halbach VV, Lawton MT, Gress DR, McCulloch CE, Young WL: Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centers. Stroke, 33 (3): 675-9, 2002 PubMed abstract
Young WL, Lawton MT, Gupta DK, Hashimoto T: Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping. Anesthesiology 96 (2): 497-503, 2002 PubMed abstract
Quick CM, Leonard EF, Young WL: Adaptation of the cerebral circulation to brain arteriovenous malformations increases feeding artery pressure and decreases regional hypotension. Neurosurgery 50: 167-175, 2002 PubMed abstract
2001
Hashimoto T, Young WL: Anesthesia-related considerations for cerebral arteriovenous malformations. Neurosurg Focus, 11 (5): Article 5, 2001 complete paper
Yang GY, Pang L, Ge HL, Tan M, Wu DC, Ye W, Huang FP, Liu XH, Che XM, Song Y, Wen R, Sun Y: Attenuation of ischemia-induced brain damage in mice by SAG, a redox inducible, antioxidant protein. J Cereb Blood Flow Metab. 2001:21: 722-733 PubMed abstract
Quick CM, Hashimoto T, Young WL: Lack of flow regulation may explain the development of arteriovenous malformations. Neurol Res 23: 641-644, 2001 PubMed abstract
Hashimoto T, Lam T, Boudreau NJ, Bollen AW, Lawton MT, Young WL: Abnormal balance in the angiopoietin-Tie2 system in human brain arteriovenous malformations. Circulation Research 89(2):111-3, 2001 PubMed abstract
Hashimoto T, Mesa-Tejada R, Quick CM, Bollen AW, Joshi S, Pile-Spellman J, Lawton MT, Young, WL: Evidence of increased endothelial cell turnover in brain arteriovenous malformations. Neurosurgery 49(1):124-132, 2001 PubMed abstract
Pang L, Ye W, Che XM, Roessler BJ, Betz AL, Yang GY: Reduction of inflammatory response in the mouse brain with adenoviral mediated transforming growth factor-beta 1 expression. Stroke 2001; 32: 544-555 PubMed abstract
Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials. Stroke 32:1430-42, 2001 PubMed abstract
Ogilvy CS, Stieg PE, Awad I, Brown RD, Jr., Kondziolka D, Rosenwasser R, Young WL, Hademenos G: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the stroke council, american stroke association. Circulation 103:2644-57, 2001 PubMed abstract
Marshall RS, Lazar RM, Pile-Spellman J, Young WL, Duong DH, Joshi S, Ostapkovich N. Recovery of brain function during induced cerebral hypoperfusion. Brain Jun;124(Pt 6):1208-1217, 2001 PubMed abstract
Joshi S, Hashimoto T, Ostapkovich N, Pile-Spellman J, Duong DH, Hacien-Bey L, Marshall RS, James DJ, Young WL. Effect of intracarotid papaverine on human cerebral blood flow and vascular resistance during acute hemispheric arterial hypotension. Journal of Neurosurgical Anesthesiology. Apr;13(2):146-51, 2001 PubMed abstract
Quick CM, Berger DS, Noordergraaf A: Constructive and destructive addition of forward and reflected arterial pulse waves. American Journal of Physiology. Heart and Circulatory Physiology 280: H1519-H1527, 2001 PubMed abstract
Quick CM, Young WL, Noordergraaf A: Infinite solutions to the hemodynamic inverse problem. American Journal of Physiology. Heart and Circulatory Physiology 280(4):H1472-H1479, 2001 PubMed abstract

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